Paul Tucker, deputy governor for financial stability at the Bank of England, is to leave later this year after more than 30 years of service.
Tucker (pictured) will spend "a period of time" in academia in the US when he leaves the Bank this autumn.
Until then he will provide support to new governor Mark Carney in the first months of the latter's term in office.
Tucker, who joined the BoE in 1980 and became deputy governor in 2009, will also continue to be an active member of the G20 Financial Stability Board (FSB) and other committees.
"I am very proud that, through the Bank and the wider central banking community, I have been able to make a contribution to monetary and financial stability," he said.
"I will continue to do so in the coming months. I am looking forward to supporting Mark Carney as he arrives at the Bank."
"It has been an enormous privilege to work closely with Paul at the FSB over the past several years. Paul has contributed immeasurably to a series of critical financial reforms, including policies to end ‘Too Big To Fail' and to build more resilient derivative and funding markets," said Carney.
"I wish Paul every success in the next phase of his career and look forward to maintaining our close dialogue on how to build a more resilient financial system that more effectively serves the needs of the real economy."