The government has responded to the "betrayal" highlighted in the Francis Inquiry with plans to overhaul the NHS.
Health Secretary Jeremy Hunt announced that a new strategy would mark the end of targets and box ticking that led to the failings at Stafford Hospital.
Hunt said: "The events at Stafford Hospital were a betrayal of the worst kind. A betrayal of the patients, of the families, and of the vast majority of NHS staff who do everything in their power to give their patients the high quality, compassionate care they deserve.
"The health and care system must change. We cannot merely tinker around the edges - we need a radical overhaul with high quality care and compassion at its heart. Today I am setting out an initial response to Robert Francis' recommendations. But this is just the start of a fundamental change to the system."
The response outlined that hospitals and care homes will be part of the shake-up including care training and better communication with families and patients.
Measures include Ofsted-style ratings for hospitals and care homes and a pilot programme that will see nurses working up to a year as a healthcare assistant as a prerequisite for receiving funding for degree study.
The response is accompanied by a statement of common purpose signed by the chairs of health and acre systems organisations.
It includes pledges to; work together for patients; treat patients and families with compassion, dignity and respect; and listen to patients and act on feedback.
Plans in the response also include; a new regulatory model under a strong, independent chief inspector of hospitals, who will develop hospital performance ratings that will show quality of cancer services.
And a new chief inspector of social care will ensure the same framework is applied in the health and care system. The merits of having a chief inspector of primary care are also being explored.
The NHS Confederation will review how we can reduce the bureaucratic burden on frontline staff and NHS providers by a third.
Mike Farrar, chief executive of the NHS Confederation, said: "The response finds the right balance between external assurance measures and internal changes focused on transforming the NHS culture.
"Only by being fully transparent can organisations learn how to improve when things go wrong. We need to listen to patients and act on their genuine concerns. The failure to do this at Mid Staffs resulted in tragic consequences - we cannot let that happen again."
Other measures outline plans to detect and deal with problems quickly, identify accountability for wrongdoers, and monitoring of leadership and motivation of NHS and social care staff.
Hunt said: "If something should go wrong, then those mistakes will be admitted, the patient told about them and steps taken to rectify them with proper accountability."
Further consultation is expected later in the year on further changes with the aim of incorporating further recommendations made by Robert Francis QC.
